Ukeleles vs. Guitars

I always wondered how different playing a ukulele was to playing a traditional guitar. Browsing some ukulele from guitar center just made me think about the differences a bit again today, but I've never actually picked one up before. The sound is completely different of course and much more twangy, and they have less strings for one. At least the traditional ukulele anyways. I guess it would compare more with a bass guitar in that regard, although their sounds share nothing in common.